The initial Mortals setting was actually for GURPS, and was written around 1995. The main difference was that there were a large number of alien species, though most of them were fairly aloof and would never involve themselves in player actions. It has fairly high tech, and suffered the problem of too many cool toys and gadgets for PCs to play with.
Recently, some of the ideas have been recycled for use as an alternative setting for the Ground Zero Games Full Thrust game, with the nations of the GZG setting being mapped to the nations of the Mortals background, minus any aliens.
At various points, there have been attempts to put artificial limits on the use and availability of computer tech, with recent Machine Wars being responsible for a restriction on their use (similar to the background of Dune). This was to force the action to focus on characters and physical action, rather than on information technology.